Title : Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry.

Pub. Date : 2003 Sep 26

PMID : 12857734






1 Functional Relationships(s)
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1 Immunological and mass spectrometric approaches coupled with two-dimensional PAGE have been used to show that peroxynitrite modification resulting in a 3-nitrotyrosine signature is predominantly associated with the complex I subunits, 49-kDa subunit (NDUFS2), TYKY (NDUFS8), B17.2 (17.2-kDa differentiation associated protein), B15 (NDUFB4), and B14 (NDUFA6). 3-nitrotyrosine NADH:ubiquinone oxidoreductase core subunit S2 Bos taurus