Pub. Date : 2003 Jul
PMID : 12853346
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Eicosapentaenoic acid restores tamoxifen sensitivity in breast cancer cells with high Akt activity. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Activation of Akt, a downstream mediator in the phosphatidylinositol 3-kinase (PI3K) signaling pathway has been implicated as one of the mechanisms involved in tamoxifen resistance. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Inhibition of PI3K restores apoptotic response to tamoxifen in hyperactive Akt cells. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Co-treatment with EPA renders breast cancer cells that overexpress a constitutively active Akt more responsive to the growth inhibitory effects of tamoxifen by approximately 35%. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | CONCLUSIONS: These findings suggest that EPA may be useful for the treatment of tamoxifen-resistant breast cancer cells with high levels of activated Akt and provide the rationale to test this hypothesis in the clinic. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |