Pub. Date : 2003 Aug
PMID : 12849728
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Predictive value of comparative molecular field analysis modelling of naphthalene inhibition of human CYP2A6 and mouse CYP2A5 enzymes. | naphthalene | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 2 | The objects of this study were first to compare how well the recently constructed structure-inhibition activity relationship models of mouse CYP2A5 and human CYP2A6 predict the interaction of naphthalene in liver microsomes and secondly to study if these CYP enzymes actually oxidize naphthalene. | naphthalene | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 3 | The CoMFA model of CYP2A5 predicted the IC(50) value of naphthalene to be 42 microM (18-115 microM 95% CL) whereas in the in vitro experiment the result was 74 microM (65-83 microM) with the corresponding values for CYP2A6 being 41 microM (18-112 microM) and 25 microM (21-30 microM), respectively. | naphthalene | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 4 | Naphthalene appeared to be a competitive inhibitor both for mouse and human liver microsomal coumarin 7-hydroxylase, which is the specific probe activity for CYP2A5 and CYP2A6. | naphthalene | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 5 | Naphthalene appeared to be a competitive inhibitor both for mouse and human liver microsomal coumarin 7-hydroxylase, which is the specific probe activity for CYP2A5 and CYP2A6. | naphthalene | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 6 | These results indicate that in silico CoMFA models predict relatively well the interaction of naphthalene with CYP2A5 and CYP2A6 and that these CYPs actually oxidize naphthalene in vitro. | naphthalene | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |