Title : The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro.

Pub. Date : 2003 Jun 12

PMID : 12848898






1 Functional Relationships(s)
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1 The transcription of key ER proteins including GADD153, PERK, GRP78, PDI, GRP94 and calreticulin were up-regulated by mefloquine, suggesting that the drug induced an ER stress response. Mefloquine calreticulin Rattus norvegicus