Title : Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice.

Pub. Date : 2003 Jul

PMID : 12829995






2 Functional Relationships(s)
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1 In the present study, amineptine, amiodarone, pirprofen, tetracycline, and tianeptine, but not doxycycline, inhibited MTP activity in vitro, decreased ex vivo MTP activity in the hepatic homogenate of treated mice, decreased TG in the luminal VLDL fraction of hepatic microsomes of treated mice, and decreased in vivo hepatic lipoprotein secretion (TG and Apo B). tianeptine microsomal triglyceride transfer protein Mus musculus
2 In the present study, amineptine, amiodarone, pirprofen, tetracycline, and tianeptine, but not doxycycline, inhibited MTP activity in vitro, decreased ex vivo MTP activity in the hepatic homogenate of treated mice, decreased TG in the luminal VLDL fraction of hepatic microsomes of treated mice, and decreased in vivo hepatic lipoprotein secretion (TG and Apo B). tianeptine microsomal triglyceride transfer protein Mus musculus