Pub. Date : 2003 Jul 15
PMID : 12826269
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Immunosuppressant PG490 (triptolide) induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells. | triptolide | caspase 3 | Homo sapiens |
| 2 | Immunosuppressant PG490 (triptolide) induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells. | triptolide | caspase 3 | Homo sapiens |
| 3 | Caspase inhibitors significantly reduced triptolide-induced caspase-3 activation. | triptolide | caspase 3 | Homo sapiens |
| 4 | The data collectively indicate that the cytotoxic effect of triptolide in U937 cells is attributable to apoptosis mediated by the caspase-3 activation pathway that may be associated with XIAP down-regulation. | triptolide | caspase 3 | Homo sapiens |