Title : Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions.

Pub. Date : 2003 Jul 8

PMID : 12824470






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Furthermore, via the consensus cholesterol recognition motif at its C terminus, Nef bound cholesterol. Cholesterol S100 calcium binding protein B Homo sapiens
2 Furthermore, via the consensus cholesterol recognition motif at its C terminus, Nef bound cholesterol. Cholesterol S100 calcium binding protein B Homo sapiens
3 When this sequence was mutated, Nef became unable to transport newly synthesized cholesterol into lipid rafts and viral particles. Cholesterol S100 calcium binding protein B Homo sapiens
4 Thus, Nef also transports newly synthesized cholesterol to the site of viral budding. Cholesterol S100 calcium binding protein B Homo sapiens