Pub. Date : 2003 Jul
PMID : 12819788
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we show that a small GTPase of the Rho family, Rac, is regulated by cAMP in a PKA-independent manner. | Cyclic AMP | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | We also show that Rac activation results from activation of Rap1 through the cAMP guanine nucleotide-exchange factor (GEF) Epac1. | Cyclic AMP | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Our data identify an unsuspected connection between two families of small GTPases and imply that Rac can function downstream of cAMP/Epac1/Rap1 in a novel signal transduction secretory pathway. | Cyclic AMP | AKT serine/threonine kinase 1 | Homo sapiens |