Pub. Date : 2003 Jul
PMID : 12814665
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP2B6 metabolizes drugs such as nicotine and bupropion, and many toxins and carcinogens. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | Nicotine induces CYP2B1 in rat brain and in humans polymorphic variation in CYP2B6 affects smoking cessation rates. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | Higher brain CYP2B6 activity in smokers and alcoholics may cause altered sensitivity to centrally acting drugs, increased susceptibility to neurotoxins and carcinogenic xenobiotics and contribute to central tolerance to nicotine. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |