Pub. Date : 2003
PMID : 12814330
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Since CD4 T lymphocyte activation is essential for virus replication and CD8 T lymphocyte activation may contribute to pathogenesis, the combination of hydroxyurea with other drugs may lead to the inhibition of HIV, by blocking the "cell activation-virus production-pathogenesis" cycle. | Hydroxyurea | CD8a molecule | Homo sapiens |
| 2 | Clinical data indicate that hydroxyurea may play a role in attenuation of viral rebound and immune reconstitution by decreasing CD4 T cell proliferation, as well as preventing the exhaustion of CD8 T cell populations that may result from excessive activation during HIV infection. | Hydroxyurea | CD8a molecule | Homo sapiens |