Title : Flavopiridol enhances the effect of docetaxel in vitro and in vivo in human gastric cancer cells.

Pub. Date : 2003 Jun

PMID : 12813134






2 Functional Relationships(s)
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1 Flavopiridol treatment of docetaxel-treated cells enhances the exit from mitosis with a more rapid decrease in mitotic markers including MPM-2 labeling and cyclin B1/cdc2 kinase activity. alvocidib cyclin B1 Homo sapiens
2 In contrast, pretreatment with flavopiridol prevents cells from entering mitosis by inhibiting cyclin B1/cdc-2 kinase activity, thus antagonizing the docetaxel effect. alvocidib cyclin B1 Homo sapiens