Pub. Date : 2003 Jun 15
PMID : 12810639
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) catalyze the oxidative metabolism of 17 beta-estradiol (E2) to catechol estrogens (2-OHE2 and 4-OHE2) and estrogen quinones, which may lead to DNA damage. | catechol | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 2 | Using purified recombinant enzymes, we demonstrated that CYP1A1 and CYP1B1 O-demethylated the methoxyestrogens to catechol estrogens according to Michaelis-Menten kinetics. | catechol | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |