Title : Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells.

Pub. Date : 2003 Sep 15

PMID : 12791666






3 Functional Relationships(s)
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1 Here, we show that prostaglandin E2 (PGE2) mediates the effects of bFGF and VEGF in up-regulating CXCR4 expression on human microvascular endothelial cells (HMECs). Dinoprostone vascular endothelial growth factor A Homo sapiens
2 Here, we show that prostaglandin E2 (PGE2) mediates the effects of bFGF and VEGF in up-regulating CXCR4 expression on human microvascular endothelial cells (HMECs). Dinoprostone vascular endothelial growth factor A Homo sapiens
3 These findings indicate that PGE2 is a mediator of VEGF- and bFGF-induced CXCR4-dependent neovessel assembly in vivo and show that angiogenic effects of PGE2 require CXCR4 expression. Dinoprostone vascular endothelial growth factor A Homo sapiens