Title : Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme.

Pub. Date : 2003 Jun

PMID : 12791252






1 Functional Relationships(s)
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1 We have determined the crystal structures of a catalytically active C-terminal deletion form of human MK2, residues 41-364, in complex with staurosporine at 2.7 A and with ADP at 3.2 A, revealing overall structural similarity with other Ser/Thr kinases. Adenosine Diphosphate MAPK activated protein kinase 2 Homo sapiens