Title : The inhibition of superoxide production in EL4 lymphoma cells overexpressing growth hormone.

Pub. Date : 2003 May

PMID : 12784910






8 Functional Relationships(s)
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1 The inhibition of superoxide production in EL4 lymphoma cells overexpressing growth hormone. Superoxides growth hormone Mus musculus
2 Since, it has been found that exogenous growth hormone (GH) primes neutrophils for the production of reactive oxygen intermediates (ROI) and in particular superoxide (O2-), we investigated the role of GH on the production of O2- in T cells. Superoxides growth hormone Mus musculus
3 Since, it has been found that exogenous growth hormone (GH) primes neutrophils for the production of reactive oxygen intermediates (ROI) and in particular superoxide (O2-), we investigated the role of GH on the production of O2- in T cells. Superoxides growth hormone Mus musculus
4 Since, it has been found that exogenous growth hormone (GH) primes neutrophils for the production of reactive oxygen intermediates (ROI) and in particular superoxide (O2-), we investigated the role of GH on the production of O2- in T cells. Superoxides growth hormone Mus musculus
5 Since, it has been found that exogenous growth hormone (GH) primes neutrophils for the production of reactive oxygen intermediates (ROI) and in particular superoxide (O2-), we investigated the role of GH on the production of O2- in T cells. Superoxides growth hormone Mus musculus
6 Our studies show that overexpression of GH in EL4, a T-cell lymphoma cell line, results in a decrease in the production of O2- compared to control cells, as detected using the fluorescent dye, dihydroethidium. Superoxides growth hormone Mus musculus
7 However, treatment with diallyl sulfide, an inhibitor of cytochrome P450 2E1 mimicked the reduction in O2- production seen in cells overexpressing GH. Superoxides growth hormone Mus musculus
8 Both the decrease in O2- production and the lower CYP2E1 activity in GH overexpressing cells could be abrogated by treatment with N(G)-monomethyl-L-arginine, an inhibitor of nitric oxide synthase. Superoxides growth hormone Mus musculus