Pub. Date : 2003 Jun 13
PMID : 12767922
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we show that topoisomerase II inhibitors, genistein and etoposide, induce p21(WAF1/Cip1) expression mainly in a p53-dependent manner in human lung cancer cell line A549. | Genistein | tumor protein p53 | Homo sapiens |
| 2 | These data suggest that both genistein and etoposide induce p21(WAF1/Cip1) expression in a p53-dependent manner. | Genistein | tumor protein p53 | Homo sapiens |
| 3 | Genistein appears to stimulate p21(WAF1/Cip1) expression through p53 via ATM, whereas etoposide may activate both ATM and ATR pathways. | Genistein | tumor protein p53 | Homo sapiens |