Title : Post-transcriptional expression of DMT1 in the heart of rat.

Pub. Date : 2003 Jul

PMID : 12767048






7 Functional Relationships(s)
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Protein Name
Organism
1 The understanding of the role of DMT1 in heart iron metabolism is fundamental for elucidating the cause resulting in excessive iron in the heart. Iron RoBo-1 Rattus norvegicus
2 The understanding of the role of DMT1 in heart iron metabolism is fundamental for elucidating the cause resulting in excessive iron in the heart. Iron RoBo-1 Rattus norvegicus
3 The study was to evaluate effects of age and dietary iron on DMT1 mRNA expression and protein synthesis in rat heart. Iron RoBo-1 Rattus norvegicus
4 During different ages, the levels of DMT1 (IRE) mRNA were higher than those of DMT1 (non-IRE) mRNA and were significantly correlated with the non-heme iron contents in the heart. Iron RoBo-1 Rattus norvegicus
5 After fed a high iron for 6 weeks, the rats had a sixfold elevation in heart iron and 22% (non-IRE from) and 40% (IRE from) reduction in DMT1 protein compared to the controls. Iron RoBo-1 Rattus norvegicus
6 A low iron diet for 6-weeks caused cardiac hypertrophy and heart iron deficiency and also an increase in levels of two forms of DMT1 proteins. Iron RoBo-1 Rattus norvegicus
7 The results demonstrated that DMT1 mRNAs expression in the heart is age-dependent and that two forms of DMT1 mRNAs both are regulated by iron on the post-transcriptional level only. Iron RoBo-1 Rattus norvegicus