Title : Angiogenic actions of angiopoietin-1 require endothelium-derived nitric oxide.

Pub. Date : 2003 Jun

PMID : 12759249






1 Functional Relationships(s)
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1 Capillary-like tube formation induced by Ang1* in fibrin matrix at 24 hours (differentiation index, DI: 13.74 +/- 0.76 versus control 1.71 +/- 0.31) was abolished in the presence of the selective PI3-kinase inhibitor, LY294002 (50 micro mol/L) (DI: 0.31 +/- 0.31, P < 0.01) or the NOS inhibitor, L-NAME (3 mmol/L) (DI: 4.10 +/- 0.59, P < 0.01). NG-Nitroarginine Methyl Ester angiopoietin 1 Homo sapiens