Pub. Date : 2003 Jun
PMID : 12756210
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interaction of buprenorphine and its metabolite norbuprenorphine with cytochromes p450 in vitro. | Buprenorphine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | In this study, the selective probe reactions for each of the major hepatic cytochromes P450 (P450s) were used to evaluate the effect of buprenorphine and its main metabolite norbuprenorphine on the activity of these P450s. | Buprenorphine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | In this study, the selective probe reactions for each of the major hepatic cytochromes P450 (P450s) were used to evaluate the effect of buprenorphine and its main metabolite norbuprenorphine on the activity of these P450s. | Buprenorphine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | In this study, the selective probe reactions for each of the major hepatic cytochromes P450 (P450s) were used to evaluate the effect of buprenorphine and its main metabolite norbuprenorphine on the activity of these P450s. | Buprenorphine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | The present in vitro study suggests that buprenorphine and its major metabolite norbuprenorphine are inhibitors of CYP2D6 and CYP3A4; however, at therapeutic concentrations they are not predicted to cause potentially clinically important drug interactions with other drugs metabolized by major hepatic P450s. | Buprenorphine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |