Pub. Date : 2003 Jun
PMID : 12755906
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Within this space, benazeprilat was bound nonlinearly to ACE, which was mainly tissular (89.4%) rather than circulating (10.6%). | benazeprilat | angiotensin I converting enzyme | Felis catus |
| 2 | Nevertheless, inhibition of ACE was long-lasting (t1/2 16-23 h) due to high affinity binding of benazeprilat to ACE (Kd approximately 3.5 mmol/L, IC50 approximately 4.3 mmol/L). | benazeprilat | angiotensin I converting enzyme | Felis catus |
| 3 | Nevertheless, inhibition of ACE was long-lasting (t1/2 16-23 h) due to high affinity binding of benazeprilat to ACE (Kd approximately 3.5 mmol/L, IC50 approximately 4.3 mmol/L). | benazeprilat | angiotensin I converting enzyme | Felis catus |
| 4 | Simulations using the model predict a lack of proportionality between dose of benazepril, plasma benazeprilat concentrations and effect due to the nonlinear binding of benazeprilat to ACE. | benazeprilat | angiotensin I converting enzyme | Felis catus |