Pub. Date : 2003 Jun
PMID : 12753388
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of MAPK, tyrosine phosphorylation of a previously described 280-kDa protein, and melanosome aggregation are sensitive to PD98059, a selective inhibitor of MAPK kinase. | Tyrosine | mitogen-activated protein kinase 1 S homeolog | Xenopus laevis |
| 2 | In addition to inhibition of cyclic adenosine 3",5"-monophosphate (cAMP), reduction in protein kinase A activity (PKA), and activation of protein phosphatase 2A, we suggest that melatonin receptors activate the MAPK cascade and tyrosine phosphorylation of the 280-kDa protein. | Tyrosine | mitogen-activated protein kinase 1 S homeolog | Xenopus laevis |