Title : Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2.

Pub. Date : 2003 Jun

PMID : 12743010






1 Functional Relationships(s)
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1 Inhibition of p38 (with SB 203580), ERK 44/42 (with UO126 or PD 98059), or COX-2 (with NS398) each significantly suppressed uric acid-induced MCP-1 expression at 24 hours, implicating these pathways in the response to uric acid. SB 203580 C-C motif chemokine ligand 2 Homo sapiens