Title : Development of resistance to a trinuclear platinum complex in ovarian carcinoma cells.

Pub. Date : 2003 Jul 10

PMID : 12740909






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cisplatin induced an appreciable increase of p21(WAF1) levels in both models, in contrast to BBR3464 that produced a substantial upregulation of p21(WAF1) only in parental cells. Cisplatin cyclin dependent kinase inhibitor 1A Homo sapiens
2 Cisplatin induced an appreciable increase of p21(WAF1) levels in both models, in contrast to BBR3464 that produced a substantial upregulation of p21(WAF1) only in parental cells. Cisplatin cyclin dependent kinase inhibitor 1A Homo sapiens
3 An inverse relationship with p21(WAF1) modulation was found for CHK1 in parental cells treated with both agents and in resistant cells treated with cisplatin. Cisplatin cyclin dependent kinase inhibitor 1A Homo sapiens
4 An inverse relationship with p21(WAF1) modulation was found for CHK1 in parental cells treated with both agents and in resistant cells treated with cisplatin. Cisplatin cyclin dependent kinase inhibitor 1A Homo sapiens