Title : Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency.

Pub. Date : 2003 Jul

PMID : 12730618






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 GSTZ1-1 is inactivated by dichloroacetic acid (DCA), which is used for the clinical management of congenital lactic acidosis and is a drinking-water contaminant. Dichloroacetic Acid glutathione S-transferase zeta 1 Rattus norvegicus
2 GSTZ1-1 is inactivated by dichloroacetic acid (DCA), which is used for the clinical management of congenital lactic acidosis and is a drinking-water contaminant. Dichloroacetic Acid glutathione S-transferase zeta 1 Rattus norvegicus
3 These data indicate that DCA-induced inactivation of GSTZ1-1 leads to formation of an MAA-derived intermediate, MA, that may be a mediator and biomarker for DCA-associated toxicities. Dichloroacetic Acid glutathione S-transferase zeta 1 Rattus norvegicus
4 These data indicate that DCA-induced inactivation of GSTZ1-1 leads to formation of an MAA-derived intermediate, MA, that may be a mediator and biomarker for DCA-associated toxicities. Dichloroacetic Acid glutathione S-transferase zeta 1 Rattus norvegicus