Title : Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.

Pub. Date : 2003 May 8

PMID : 12723961






1 Functional Relationships(s)
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1 The inhibitory potency of these thiol-based compounds against GCP II was found to be dependent on the number of methylene units between the thiol group and pentanedioic acid. glutaric acid folate hydrolase 1 Rattus norvegicus