Title : NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols.

Pub. Date : 2003 Jul 11

PMID : 12719428






1 Functional Relationships(s)
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1 Moreover, we demonstrate that treatment with oxysterols reduces cholesterol in NPC mutants and is able to correct the NPC1I1061T phenotype, the most prevalent NPC1 disease genotype. Oxysterols NPC intracellular cholesterol transporter 1 Homo sapiens