Title : Iron chelators inhibit VCAM-1 expression in human dermal microvascular endothelial cells.

Pub. Date : 2003 May

PMID : 12713595






2 Functional Relationships(s)
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1 The effect of iron was mediated at the level of gene transcription since pretreatment with DP abrogated the TNF alpha-mediated up-regulation of VCAM-1 heterogeneous nuclear RNA. 2,2'-Dipyridyl tumor necrosis factor Homo sapiens
2 DP pretreatment inhibited TNF alpha- and IFN gamma-mediated interferon regulatory factor 1 (IRF-1) protein expression, although restoration of IRF-1 expression failed to reconstitute VCAM-1 expression. 2,2'-Dipyridyl tumor necrosis factor Homo sapiens