Title : Localization of the calcitonin gene-related peptide receptor complex at the vertebrate neuromuscular junction and its role in regulating acetylcholinesterase expression.

Pub. Date : 2003 Jul 4

PMID : 12707285






1 Functional Relationships(s)
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1 Using tissue-cultured skeletal muscle we show that CGRP stimulates an increase in intracellular cAMP that in turn initiates down-regulation of acetylcholinesterase expression at the transcriptional level, and, more specifically, inhibits expression of the synaptically localized collagen-tailed form of the enzyme. Cyclic AMP acetylcholinesterase (Cartwright blood group) Homo sapiens