Title : Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene.

Pub. Date : 2003 Apr 25

PMID : 12705905






2 Functional Relationships(s)
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1 Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene. pregna-4,17-diene-3,16-dione cytochrome P450 family 7 subfamily A member 1 Homo sapiens
2 On the other hand, guggulsterone has no effect on FXR inhibition of the CYP7A1 gene, but strongly inhibits the human CYP7A1 gene by activation of pregnane X receptor (PXR). pregna-4,17-diene-3,16-dione cytochrome P450 family 7 subfamily A member 1 Homo sapiens