Title : Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells.

Pub. Date : 2003 May

PMID : 12704209






3 Functional Relationships(s)
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Protein Name
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1 The cognate proteins, HFE and TfR2, are therefore of key importance in human iron homeostasis. Iron transferrin receptor 2 Homo sapiens
2 In human Caco-2 cells, HFE and TfR2 co-localized to a distinct CD63-negative vesicular compartment showing marked signal enhancement on exposure to iron-saturated transferrin ligand, indicating that HFE preferentially interacts with TfR2 in a specialized early endosomal transport pathway for transferrin-iron. Iron transferrin receptor 2 Homo sapiens
3 In human Caco-2 cells, HFE and TfR2 co-localized to a distinct CD63-negative vesicular compartment showing marked signal enhancement on exposure to iron-saturated transferrin ligand, indicating that HFE preferentially interacts with TfR2 in a specialized early endosomal transport pathway for transferrin-iron. Iron transferrin receptor 2 Homo sapiens