Title : Structural model of the N-methyl-D-aspartate receptor glycine site probed by site-directed chemical coupling.

Pub. Date : 2003 Jun 27

PMID : 12697759






1 Functional Relationships(s)
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1 Together these inactivating substitutions identified seven NR1 residues (Ile-385, Gln-387, Glu-388, Thr-500, Asn-502, Ala-696, and Val-717) that undergo proximity-induced covalent coupling with specific regions of the bound antagonist and disclose its mode of docking in the glycine binding pocket of the NMDA receptor. Asparagine glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis