Title : Caffeine mimics adenine and 2'-deoxyadenosine, both of which inhibit the guanine-nucleotide exchange activity of RCC1 and the kinase activity of ATR.

Pub. Date : 2003 May

PMID : 12694532






4 Functional Relationships(s)
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1 Caffeine mimics adenine and 2"-deoxyadenosine, both of which inhibit the guanine-nucleotide exchange activity of RCC1 and the kinase activity of ATR. 2'-deoxyadenosine serine/threonine-protein kinase ATR Mesocricetus auratus
2 We found that both adenine and 2"-dA, but none of the other 2"-deoxynucleosides, inhibited the kinase activity of ATR, similar to that of caffeine. 2'-deoxyadenosine serine/threonine-protein kinase ATR Mesocricetus auratus
3 CONCLUSION: The effect of caffeine on cell-cycle control mimics the biological effect of adenine and 2"-dA, both of which inhibit ATR. 2'-deoxyadenosine serine/threonine-protein kinase ATR Mesocricetus auratus
4 dATP, a final metabolite of adenine and 2"-dA, is suggested to inhibit ATR, resulting in PCC. 2'-deoxyadenosine serine/threonine-protein kinase ATR Mesocricetus auratus