Title : Selective roles of protein kinase C isoforms on cell motility of GT1 immortalized hypothalamic neurones.

Pub. Date : 2003 May

PMID : 12694376






1 Functional Relationships(s)
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1 Both wound-healing and Boyden migration assays showed that TPA treatment promoted neuronal migration of GT1 cells; however, cotreatment of TPA with safingol or rottlerin (a PKC delta-selective inhibitor) clearly blocked this TPA effect, indicating that both PKC alpha and PKC delta may be positive regulators of neuronal migration. safingol beta-1,4-galactosyltransferase 1 Homo sapiens