Title : Effect of opioid receptor antagonists on hypothalamic-pituitary-adrenal activity in rhesus monkeys.

Pub. Date : 2003 May

PMID : 12689609






3 Functional Relationships(s)
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1 Naltrexone, 0.1-1.0 mg/kg, increased ACTH levels, whereas naltrindole and clocinnamox failed to increase ACTH levels. Naltrexone proopiomelanocortin Homo sapiens
2 Alternatively, the naltrexone-induced increase of ACTH and cortisol plasma levels may be caused by activity at multiple opioid receptors or some uncharacterized receptor. Naltrexone proopiomelanocortin Homo sapiens
3 Finally, the increased release of ACTH and cortisol may be a response to naltrexone"s aversive properties. Naltrexone proopiomelanocortin Homo sapiens