Title : Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver.

Pub. Date : 2003 Jan

PMID : 12674509






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Upon stimulation of JAK2 tyrosine phosphorylation, leptin induced JAK2 co-immunoprecipitation with STAT3, STAT5b, IRS-1 and IRS-2. Tyrosine signal transducer and activator of transcription 3 Rattus norvegicus
2 This phenomenon parallels the leptin-induced tyrosine phosphorylation of STAT3, STAT5b, IRS-1 and IRS-2. Tyrosine signal transducer and activator of transcription 3 Rattus norvegicus
3 Acutely injected insulin stimulated a mild increase in tyrosine phosphorylation of JAK2, STAT3 and STAT5b. Tyrosine signal transducer and activator of transcription 3 Rattus norvegicus