Pub. Date : 2003 May 30
PMID : 12665509
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glucose regulates insulin gene transcription by hyperacetylation of histone h4. | Glucose | LOC102641229 | Mus musculus |
| 2 | We report that exposure of mouse insulinoma 6 cells to high concentrations of glucose results in hyperacetylation of histone H4 at the insulin gene promoter, which correlates with the increased level of insulin gene transcription. | Glucose | LOC102641229 | Mus musculus |
| 3 | In addition, we demonstrate that hyperacetylation of histone H4 in response to high concentrations of glucose also occurs at the glucose transporter-2 gene promoter. | Glucose | LOC102641229 | Mus musculus |
| 4 | In summary, our data support the idea that high concentrations of glucose stimulate insulin gene expression by causing hyperacetylation of histone H4 at the insulin gene promoter. | Glucose | LOC102641229 | Mus musculus |