Title : Inhibition of phosphatidylinositol 3-kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis.

Pub. Date : 2003 Jun 6

PMID : 12663669






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cycloheximide but not LY294002 decreases expression of c-FLIP (cellular FLICE inhibitory protein), an inhibitor of caspase-8 activation. Cycloheximide caspase 8 Homo sapiens
2 The caspase inhibitor zVADfmk completely blocks caspase activation, DNA degradation, and nuclear fragmentation in both cases but only prevents loss of DeltaPsi and cell death for cytokine plus cycloheximide treatment. Cycloheximide caspase 8 Homo sapiens