Title : Activation of p53 by the cytoprotective aminothiol WR1065: DNA-damage-independent pathway and redox-dependent modulation of p53 DNA-binding activity.

Pub. Date : 2003 Apr 1

PMID : 12663048






2 Functional Relationships(s)
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1 Direct reduction by WR1065 of key cysteines in p53 may play an important role in this alternative pathway, as shown by the fact that WR1065 activated the redox-dependent, DNA-binding activity of p53 in vitro. Cysteine tumor protein p53 Homo sapiens
2 Direct reduction by WR1065 of key cysteines in p53 may play an important role in this alternative pathway, as shown by the fact that WR1065 activated the redox-dependent, DNA-binding activity of p53 in vitro. Cysteine tumor protein p53 Homo sapiens