Pub. Date : 2003 Apr
PMID : 12649382
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappaB and activator protein-1 in human monocytes. | Gabexate | tumor necrosis factor | Homo sapiens |
| 2 | Gabexate mesilate, a synthetic protease inhibitor, was shown to be effective in treating patients with sepsis-associated disseminated intravascular coagulation in which tumor necrosis factor-alpha (TNF-alpha) plays a critical role. | Gabexate | tumor necrosis factor | Homo sapiens |
| 3 | Gabexate mesilate, a synthetic protease inhibitor, was shown to be effective in treating patients with sepsis-associated disseminated intravascular coagulation in which tumor necrosis factor-alpha (TNF-alpha) plays a critical role. | Gabexate | tumor necrosis factor | Homo sapiens |
| 4 | In the present study, we analyzed the mechanism(s) by which gabexate mesilate inhibits LPS-induced TNF-alpha production in human monocytes in vitro. | Gabexate | tumor necrosis factor | Homo sapiens |
| 5 | Gabexate mesilate inhibited the production of TNF-alpha in monocytes stimulated with LPS. | Gabexate | tumor necrosis factor | Homo sapiens |
| 6 | These observations strongly suggest that gabexate mesilate inhibited LPS-induced TNF-alpha production in human monocytes by inhibiting activation of both NF-kappaB and AP-1. | Gabexate | tumor necrosis factor | Homo sapiens |
| 7 | Inhibition of TNF-alpha production by gabexate mesilate might explain at least partly its therapeutic effects in animals given LPS and those in patients with sepsis. | Gabexate | tumor necrosis factor | Homo sapiens |