Title : Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

Pub. Date : 2003 Mar 15

PMID : 12649187






6 Functional Relationships(s)
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1 To discover disrupters of aberrant STAT3 signaling pathways as novel anticancer drugs, we developed a phosphotyrosine STAT3 cytoblot. Phosphotyrosine signal transducer and activator of transcription 3 Mus musculus
2 To discover disrupters of aberrant STAT3 signaling pathways as novel anticancer drugs, we developed a phosphotyrosine STAT3 cytoblot. Phosphotyrosine signal transducer and activator of transcription 3 Mus musculus
3 JSI-124 suppressed the levels of phosphotyrosine STAT3 in v-Src-transformed NIH 3T3 cells and human cancer cells potently (IC(50) value of 500 nM in the human lung adenocarcinoma A549) and rapidly (complete inhibition within 1-2 h). Phosphotyrosine signal transducer and activator of transcription 3 Mus musculus
4 The suppression of phosphotyrosine STAT3 levels resulted in the inhibition of STAT3 DNA binding and STAT3-mediated but not serum response element-mediated gene transcription. Phosphotyrosine signal transducer and activator of transcription 3 Mus musculus
5 The suppression of phosphotyrosine STAT3 levels resulted in the inhibition of STAT3 DNA binding and STAT3-mediated but not serum response element-mediated gene transcription. Phosphotyrosine signal transducer and activator of transcription 3 Mus musculus
6 The suppression of phosphotyrosine STAT3 levels resulted in the inhibition of STAT3 DNA binding and STAT3-mediated but not serum response element-mediated gene transcription. Phosphotyrosine signal transducer and activator of transcription 3 Mus musculus