Title : Identification of immune responses against aldehyde-modified peptide sequences in apoB associated with cardiovascular disease.

Pub. Date : 2003 May 1

PMID : 12649091






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1 Identification of immune responses against aldehyde-modified peptide sequences in apoB associated with cardiovascular disease. Aldehydes apolipoprotein B Homo sapiens
2 METHODS AND RESULTS: Using a library of polypeptides covering the complete sequence of apoB-100, the only major protein of LDL, we have identified over 100 different human antibodies reacting against aldehyde-modified apoB-100 sequences. Aldehydes apolipoprotein B Homo sapiens
3 METHODS AND RESULTS: Using a library of polypeptides covering the complete sequence of apoB-100, the only major protein of LDL, we have identified over 100 different human antibodies reacting against aldehyde-modified apoB-100 sequences. Aldehydes apolipoprotein B Homo sapiens
4 In prospective clinical studies, antibody levels against several aldehyde-modified apoB-100 sites were associated with cardiovascular disease in this age group. Aldehydes apolipoprotein B Homo sapiens