Title : The mechanism of CD47-dependent killing of T cells: heterotrimeric Gi-dependent inhibition of protein kinase A.

Pub. Date : 2003 Apr 1

PMID : 12646616






2 Functional Relationships(s)
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1 Pretreatment of T cells with 8-bromo cAMP, forskolin, or 3-isobutyl-1-methylxanthine prevented the CD47-mediated apoptosis, and 1F7 dramatically reduced intracellular cAMP levels, an effect reversed with PTX. Cyclic AMP CD47 molecule Homo sapiens
2 Thus, CD47-mediated killing of activated T cells occurs by a novel pathway involving regulation of cAMP levels by heterotrimeric G((i)alpha) with subsequent effects mediated by PKA. Cyclic AMP CD47 molecule Homo sapiens