Title : The mechanism of CD47-dependent killing of T cells: heterotrimeric Gi-dependent inhibition of protein kinase A.

Pub. Date : 2003 Apr 1

PMID : 12646616






1 Functional Relationships(s)
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1 Pretreatment of T cells with 8-bromo cAMP, forskolin, or 3-isobutyl-1-methylxanthine prevented the CD47-mediated apoptosis, and 1F7 dramatically reduced intracellular cAMP levels, an effect reversed with PTX. 1-Methyl-3-isobutylxanthine CD47 molecule Homo sapiens