Pub. Date : 2003 May 23
PMID : 12646577
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Incadronate amplifies prostaglandin F2 alpha-induced vascular endothelial growth factor synthesis in osteoblasts. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 2 | In the present study, we investigated the mechanism of vascular endothelial growth factor (VEGF) synthesis induced by PGF2 alpha and the effect of incadronate on the VEGF synthesis in these cells. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 3 | In the present study, we investigated the mechanism of vascular endothelial growth factor (VEGF) synthesis induced by PGF2 alpha and the effect of incadronate on the VEGF synthesis in these cells. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 4 | PGF2 alpha significantly stimulated the VEGF synthesis in a dose-dependent manner between 1 pm and 10 microm. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 5 | PGF2 alpha increased the levels of mRNA for VEGF. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 6 | Indomethacin, an inhibitor of cyclooxygenase, significantly reduced the PGF2 alpha-induced VEGF synthesis. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 7 | Bisindolylmaleimide, an inhibitor of PKC, reduced the PGF2 alpha-induced VEGF synthesis. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 8 | The VEGF synthesis induced by PGF2 alpha was significantly attenuated in the PKC down-regulated cells. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 9 | PD98059 or U0126, inhibitors of MEK, suppressed the VEGF synthesis induced by PGF2 alpha. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 10 | Incadronate enhanced the synthesis of VEGF induced by PGF2 alpha. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 11 | PD98059 suppressed the enhancement by incadronate of PGF2 alpha-induced VEGF synthesis. | Dinoprost | vascular endothelial growth factor A | Mus musculus |
| 12 | These results strongly suggest that PGF2 alpha stimulates VEGF synthesis through the PKC-dependent activation of p44/p42 MAPK in osteoblasts and that the incadronate enhances the VEGF synthesis at the point between PKC and Raf-1. | Dinoprost | vascular endothelial growth factor A | Mus musculus |