Pub. Date : 2002 Nov-Dec
PMID : 12642691
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The histone deacetylase inhibitor FR901228 (desipeptide) restores expression and function of pseudo-null p53. | romidepsin | tumor protein p53 | Homo sapiens |
| 2 | Here we demonstrated that treatment of SW-1736 cells with sub-cytotoxic concentrations of FR901228, a histone deacetylase (HDAC) inhibitor, results in marked induction of p53 mRNA and protein. | romidepsin | tumor protein p53 | Homo sapiens |
| 3 | The p53 induced by FR901228 was functional as evidenced by mdm-2 and p21 transactivation, and its further accumulation following DNA damage by doxorubicin. | romidepsin | tumor protein p53 | Homo sapiens |