Title : Design, synthesis, and structure-activity relationships of unsubstituted piperazinone-based transition state factor Xa inhibitors.

Pub. Date : 2003 Feb 24

PMID : 12639567






1 Functional Relationships(s)
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1 A series of novel transition state factor Xa inhibitors containing a variety of lactam ring systems as central templates was synthesized in an expedient manner and allowed for a great deal of structural variability. Lactams coagulation factor X Homo sapiens