Pub. Date : 2003 Mar 1
PMID : 12629203
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glial cell line-derived neurotrophic factor increases stimulus-evoked dopamine release and motor speed in aged rhesus monkeys. | Dopamine | glial cell derived neurotrophic factor | Macaca mulatta |
| 2 | Here, we report the effects of glial cell line-derived neurotrophic factor (GDNF) on the stimulus-evoked release of dopamine and motor speed in aged monkeys (21-27 years of age; n = 10). | Dopamine | glial cell derived neurotrophic factor | Macaca mulatta |
| 3 | Here, we report the effects of glial cell line-derived neurotrophic factor (GDNF) on the stimulus-evoked release of dopamine and motor speed in aged monkeys (21-27 years of age; n = 10). | Dopamine | glial cell derived neurotrophic factor | Macaca mulatta |
| 4 | The stimulus-evoked release of dopamine was significantly increased, up to 130% in the right caudate nucleus and putamen and up to 116% in both the right and left substantia nigra of the aged GDNF recipients compared with vehicle controls. | Dopamine | glial cell derived neurotrophic factor | Macaca mulatta |
| 5 | Also, basal extracellular levels of dopamine were bilaterally increased, up to 163% in the substantia nigra of the aged GDNF-treated animals. | Dopamine | glial cell derived neurotrophic factor | Macaca mulatta |
| 6 | The data suggest that the effects of GDNF on the release of dopamine in the basal ganglia may be responsible for the improvements in motor functions and support the hypothesis that functional changes in dopamine release may contribute to motor dysfunctions characterizing senescence. | Dopamine | glial cell derived neurotrophic factor | Macaca mulatta |