Title : Prime-boost vaccination with plasmid DNA encoding caprine-arthritis encephalitis lentivirus env and viral SU suppresses challenge virus and development of arthritis.

Pub. Date : 2003 Feb 1

PMID : 12620804






1 Functional Relationships(s)
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1 Vaccination of Saanen goats with pUC-based plasmid DNA expressing CAEV env induces T helper type 1 (Th1) biased immune responses to vector-encoded surface envelope (SU), and the plasmid-primed Th1 response is expanded following boost with purified SU in Freund"s incomplete adjuvant (SU-FIA) (J. C. Beyer et al., 2001, Vaccine 19, 1643-1651). Sulfur envelope polyprotein;trans-regulatory splicing-like protein Caprine arthritis encephalitis virus