Pub. Date : 2003 Mar 1
PMID : 12614848
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation. | arsenite | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Arsenite-induced Akt phosphorylation also was inhibited by sequestrating membrane cholesterol with beta cyclodextrin. | arsenite | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Reducing reagents/reactive oxygen species (ROS) scavengers reduced arsenite-induced Akt phosphorylation and beta cyclodextrin reduced arsenite-mediated ROS production, suggesting that arsenite-induced G-protein/Akt/GSK3beta pathway is membrane raft dependent and redox linked. | arsenite | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Reducing reagents/reactive oxygen species (ROS) scavengers reduced arsenite-induced Akt phosphorylation and beta cyclodextrin reduced arsenite-mediated ROS production, suggesting that arsenite-induced G-protein/Akt/GSK3beta pathway is membrane raft dependent and redox linked. | arsenite | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | These results suggested that selective blockade of the arsenite-provoked PI-3 kinase/Akt pathway can promote the arsenite-triggered pathway for caspase activation, and this may open a new study area for wider applications of arsenic as a drug for treating various kinds of leukemia. | arsenite | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | These results suggested that selective blockade of the arsenite-provoked PI-3 kinase/Akt pathway can promote the arsenite-triggered pathway for caspase activation, and this may open a new study area for wider applications of arsenic as a drug for treating various kinds of leukemia. | arsenite | AKT serine/threonine kinase 1 | Homo sapiens |