Pub. Date : 2003 Feb 1
PMID : 12604207
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ADH4 exhibits the highest catalytic efficiency for retinol oxidation in human ADH family. | Vitamin A | alcohol dehydrogenase 4 (class II), pi polypeptide | Homo sapiens |
| 2 | ADH4 exhibits the highest catalytic efficiency for retinol oxidation in human ADH family. | Vitamin A | alcohol dehydrogenase 4 (class II), pi polypeptide | Homo sapiens |
| 3 | When functioning as retinol dehydrogenase, the mechanism of ADH4 deduced from steady-state kinetic and equilibrium-binding studies is best described as a rapid equilibrium random mechanism with two dead-end ternary complex for retinol oxidation and a rapid equilibrium ordered mechanism with one dead-end ternary complex for retinal reduction, a unique mechanistic form for zinc-containing ADHs in the medium chain dehydrogenase/reductase superfamily. | Vitamin A | alcohol dehydrogenase 4 (class II), pi polypeptide | Homo sapiens |
| 4 | Quantitative simulation studies indicate that retinol metabolism through ADH pathway can be inhibited to a significant extent during alcohol consumption. | Vitamin A | alcohol dehydrogenase 4 (class II), pi polypeptide | Homo sapiens |